Vaccine-Derived Poliovirus: From the GPEI

EradicationVaccination
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FACT SHEET from the Global Polio Eradication Initiative

“Global efforts to immunise children with the oral polio vaccine (OPV) have reduced wild poliovirus cases by 99.9% since 1988, and of the three strains of wild poliovirus, only one remains in circulation – wild polio virus type 1 (WPV1). OPV is safe and effective and interrupts person-to-person spread of polio. However, on rare occasions, and only in under-immunised populations, the live weakened virus in OPV can circulate in a community for an extended period of time and mutate into a form that causes paralysis, known as circulating vaccine-derived poliovirus (cVDPV). cVDPVs are not related to, nor indicative of a re-emergence of wild poliovirus.”

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