Cholesterol Medications
Question: I have had muscle pain taking statins for high cholesterol. Is Livalo an option?
Dr. Bruno’s Response: Statins can cause muscle pain which could be a problem for polio survivors. Livalo (pitavastatin) may be better for patients who have not tolerated other statins well and need a medication causing less muscle pain. Additionally, Livalo has fewer drug interactions compared to other statins, so it may be a good option for those who take multiple medications.
For those who can’t take statins at all, doctors can prescribe a fibrate. Like the statins, fibrates reduce the body's cholesterol production, but they are less effective in lowering LDL (“bad”) cholesterol levels. In other areas, though, fibrates actually have an edge. They are substantially better at boosting HDL levels, and only two statins -- atorvastatin (Lipitor) and rosuvastatin (Crestor) -- can match their ability to reduce triglyceride levels.
Gemfibrozil (Lopid) and Fenofibrate (TriCor)appear equally safe and effective. Fenofibrate is more convenient, since it is taken once a day, but generic gemfibrozil is substantially less expensive. The fibrates are particularly effective in patients with high triglycerides, low HDL or diabetes. However, some patients with high triglyceride levels may experience a paradoxical rise in LDL levels. Side effects are uncommon but can include liver inflammation, muscle damage, abdominal pain, gallstones, dizziness, and interactions with the anticoagulant ("blood thinner") warfarin (Coumadin). Talk to your doctor.
Cholesterol Lowering Medications and Muscle Pain in Polio Survivors is one of the articles under the topic of “Cholesterol” and “Medications” in the Index of the Encyclopedia of Polio and PPS that might help.
Here are two interesting articles that you may want to read: